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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DBI All Species: 46.97
Human Site: Y29 Identified Species: 79.49
UniProt: P07108 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07108 NP_001073331.1 87 10044 Y29 D E E M L F I Y G H Y K Q A T
Chimpanzee Pan troglodytes XP_001156427 104 11890 Y46 D E E M L F I Y G H Y K Q A T
Rhesus Macaque Macaca mulatta XP_001103096 102 11963 Y29 D D E M L F I Y G R Y K Q A T
Dog Lupus familis XP_849337 87 9960 Y29 D D E M L Y I Y S H Y K Q A T
Cat Felis silvestris
Mouse Mus musculus P31786 87 9982 Y29 D E E M L F I Y S H F K Q A T
Rat Rattus norvegicus P11030 87 10009 Y29 D E E M L F I Y S H F K Q A T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9PRL8 86 9626 Y28 D Q E M L D V Y S H Y K Q A T
Frog Xenopus laevis NP_001085947 85 9634 T28 T D E E M L E T Y A L Y K Q A
Zebra Danio Brachydanio rerio NP_955902 87 9643 Y29 D A E M L E I Y S L Y K Q A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P42281 86 9538 Y29 D D E F L Q L Y A L F K Q A S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O01805 86 9355 Y28 N D E L L K L Y A L F K Q G T
Sea Urchin Strong. purpuratus XP_784299 87 9491 Y28 N E D L L K I Y S L F K Q V T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P57752 92 10367 Y30 N E D L L I L Y G L Y K Q A K
Baker's Yeast Sacchar. cerevisiae P31787 87 10043 Y29 T D E L L E L Y A L Y K Q A T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.6 76.4 85 N.A. 78.1 78.1 N.A. N.A. 75.8 73.5 79.3 N.A. 50.5 N.A. 54 59.7
Protein Similarity: 100 83.6 83.3 96.5 N.A. 91.9 93 N.A. N.A. 88.5 81.6 87.3 N.A. 66.6 N.A. 71.2 70.1
P-Site Identity: 100 100 86.6 80 N.A. 86.6 86.6 N.A. N.A. 73.3 6.6 73.3 N.A. 46.6 N.A. 40 46.6
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. 86.6 26.6 73.3 N.A. 73.3 N.A. 73.3 73.3
Percent
Protein Identity: N.A. N.A. N.A. 44.5 48.2 N.A.
Protein Similarity: N.A. N.A. N.A. 61.9 64.3 N.A.
P-Site Identity: N.A. N.A. N.A. 53.3 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 0 22 8 0 0 0 79 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 65 43 15 0 0 8 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 43 86 8 0 15 8 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 8 0 36 0 0 0 0 36 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 29 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 43 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 58 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 15 0 0 0 0 0 93 8 0 8 % K
% Leu: 0 0 0 29 93 8 29 0 0 43 8 0 0 0 0 % L
% Met: 0 0 0 58 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 8 0 0 0 0 0 0 93 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 43 0 0 0 0 0 8 % S
% Thr: 15 0 0 0 0 0 0 8 0 0 0 0 0 0 79 % T
% Val: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 93 8 0 58 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _